Molecular mechanisms of disease-causing missense mutations
Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …
on stability, hydrogen bond network, conformational dynamics, activity and many other …
Mechanisms of chromosome congression during mitosis
Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …
Drug resistance mechanism of PncA in Mycobacterium tuberculosis
V Rajendran, R Sethumadhavan - Journal of Biomolecular …, 2014 - Taylor & Francis
Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …
In silico analysis predicting effects of deleterious SNPs of human RASSF5 gene on its structure and functions
MS Hossain, AS Roy, MS Islam - Scientific reports, 2020 - nature.com
Ras association domain-containing protein 5 (RASSF5), one of the prospective biomarkers
for tumors, generally plays a crucial role as a tumor suppressor. As deleterious effects can …
for tumors, generally plays a crucial role as a tumor suppressor. As deleterious effects can …
Use of long term molecular dynamics simulation in predicting cancer associated SNPs
Computational prediction of cancer associated SNPs from the large pool of SNP dataset is
now being used as a tool for detecting the probable oncogenes, which are further examined …
now being used as a tool for detecting the probable oncogenes, which are further examined …
CEP proteins: the knights of centrosome dynasty
Centrosome forms the backbone of cell cycle progression mechanism. Recent debates have
occurred regarding the essentiality of centrosome in cell cycle regulation. CEP family protein …
occurred regarding the essentiality of centrosome in cell cycle regulation. CEP family protein …
Network pharmacology‐based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L.
Y Xiong, Y Yang, W Xiong, Y Yao… - Journal of Cellular …, 2019 - Wiley Online Library
Rubia cordifolia L. is widely used in Asia and its antihepatoma effect has been proved by in
vitro and in vivo experiments. However, there are few studies on its specific mechanism. In …
vitro and in vivo experiments. However, there are few studies on its specific mechanism. In …
Evidence of colorectal cancer-associated mutation in MCAK: a computational report
A Kumar, V Rajendran, R Sethumadhavan… - Cell Biochemistry and …, 2013 - Springer
Computational prediction of disease-associated non-synonymous polymorphism (nsSNP)
has provided a significant platform to filter out the pathological mutations from large pool of …
has provided a significant platform to filter out the pathological mutations from large pool of …
Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer
SW Lim, KJK Tan, OM Azuraidi, M Sathiya, EC Lim… - Scientific Reports, 2021 - nature.com
MYB proteins are highly conserved DNA-binding domains (DBD) and mutations in MYB
oncoproteins have been reported to cause aberrant and augmented cancer progression …
oncoproteins have been reported to cause aberrant and augmented cancer progression …
Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain
Background AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the
most frequently activated proliferated and survival pathway of cancer. Recently it has been …
most frequently activated proliferated and survival pathway of cancer. Recently it has been …