Identification of natural compounds of the apple as inhibitors against cholinesterase for the treatment of Alzheimer's disease: an in silico molecular docking simulation …

QMS Jamal, MI Khan, AH Alharbi, V Ahmad, BS Yadav - Nutrients, 2023 - mdpi.com
Alzheimer's disease (AD), the most common type of dementia in older people, causes
neurological problems associated with memory and thinking. The key enzymes involved in …

Moroccan natural products for multitarget-based treatment of Alzheimer's disease: A computational study

FZ Guerguer, A Bouribab, EM Karim, M Khedraoui… - PloS one, 2025 - journals.plos.org
Alzheimer's disease is a neurodegenerative disorder that impairs neurocognitive functions.
Acetylcholinesterase, Butyrylcholinesterase, Monoamine Oxidase B, Beta-Secretase, and …

Synthesis, biological activity, X-ray crystallographic, molecular docking and molecular dynamics simulation studies of pyrazole-1, 3, 5-triazine derivatives as potential …

XY Xue, M Wei, Z Zhao, L Xu, Y Cao, Y Yang… - Journal of Molecular …, 2025 - Elsevier
Abstract Thirteen novel pyrazole-1, 3, 5-triazine derivatives were synthesized and assessed
for their potential as cholinesterase inhibitors. The structure of the compounds was …

Relationship between urinary dichlorophenols and cognitive function among people over 60 years old from NHANES

X Weng, H Liang, K Liu, J Chen, Q Fei, S Liu… - … Science and Pollution …, 2022 - Springer
Studies have shown that exposure to dichlorophenols (DCPs) and their precursors might
have potential neurotoxicity, which may be related to low cognitive function, but there are …

Molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, NNK and NNN

AM Thasweer, P Renuka Devi… - Journal of …, 2023 - Taylor & Francis
Smoking constitutes a major global health problem. As it triggers various health hazards
including cancers, cardiac and pulmonary illness, it is imperative to understand the …

[HTML][HTML] Liver function, kidney function, glycohemoglobin, neurotransmitters, and heart markers and factors affecting blood biochemistry among workers at gas service …

CP Polyong, A Thetkathuek - Journal of Public Health and …, 2024 - jphe.amegroups.org
Background: Workers who live near fuel sources, particularly those who work at gas stations,
are at a high risk of benzene, toluene, ethylbenzene, and xylene (BTEX) toxicity, which can …

African Natural Products for Multitarget-Based Treatment of Alzheimer's Disease: An In Silico Study

AA Ahmed, RR Babikir, TA Hassan, AAM Ahmed… - 2023 - preprints.org
Alzheimer's disease is a multifactorial neurodegenerative disorder, with
Acetylcholinesterase, Butyrylcholinesterase, Beta secretase, Glycogen Synthase Kinase …

Evaluation of acute hepatic toxicity and inflammation induced by nitrosamines in Mus musculus and Danio rerio

I Annunciato - 2024 - repositorio.unesp.br
Nitrosamines are emerging contaminants known for their carcinogenic and oxidative
properties. This study investigates the hepatotoxic and acute inflammatory effects of two …

Mutagenic factors in the environment impacting human and animal health

S Roychoudhury, NK Jha, J Ruokolainen… - … Science and Pollution …, 2022 - Springer
In our day-to-day life, mutagenic factors especially dominate in the environment and are
considered responsible for causing and/or aggravating a number of diseases. Japanese …

[PDF][PDF] MOL2NET'23, Conference on Molecular, Biomedical & Computational Sciences and Engineering

LAB Bezerraa, AFM Monteiroa, CS Ramosa - sciforum.net
2 and clinical studies. In this context, this paper summarizes two works in molecular docking
with the objective of elucidating the interaction of different nicotine and its metabolites in the …