Analytical approaches for determination of COVID-19 candidate drugs in human biological matrices

R Mahdavi, Z Talebpour - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, the use of antiviral and other available drugs
has been considered to combat or reduce the clinical symptoms of patients. In this regard, it …

[HTML][HTML] Emerging procedures and solvents in biological sample pre-treatment

V Greco, A Giuffrida, M Locatelli, F Savini… - Advances in Sample …, 2023 - Elsevier
The treatment of biological samples, especially from complex matrices, has consistently
challenged analytical operators. The classic problems to be faced for any analysis …

Novel environment friendly TLC-densitometric method for the determination of anti-coronavirus drugs “Remdesivir and Favipiravir”: Green assessment with application …

DAM Noureldeen, JM Boushra, AS Lashien… - Microchemical …, 2022 - Elsevier
A great demand for discovering new therapeutic solutions has been considered all over the
world for managing the rapidly progressing COVID-19 pandemic. Remdesivir (REM) and …

Rapid determination of remdesivir (SARS-CoV-2 drug) in human plasma for therapeutic drug monitoring in COVID-19-Patients

RR Pasupuleti, PC Tsai, VK Ponnusamy… - Process …, 2021 - Elsevier
To tackle the harmful consequences of the widespread COVID-19 pandemic, a broad-
spectrum anti-viral drug remdesivir (RDV) has gained the utmost attention recently due to its …

Rapid and ecofriendly UPLC quantification of Remdesivir, Favipiravir and Dexamethasone for accurate therapeutic drug monitoring in Covid-19 Patient's plasma

AA Emam, EA Abdelaleem, EH Abdelmomen… - Microchemical …, 2022 - Elsevier
Innovative therapeutic protocols to the rapidly spreading coronavirus disease (COVID19)
epidemic is highly required all across the world. As demonstrated by clinical studies …

Environmental impact of the reported chromatographic methods for the determination of the first FDA-Approved therapy for COVID-19 Patients, Remdesivir: A …

AB Ahmed, M Gamal, IA Naguib, HM Ali… - Microchemical …, 2022 - Elsevier
Remdesivir (REM) is considered the first therapeutic option approved by US Food and Drug
Administration (FDA) for clinical care in case of hospitalized patients suffering in COVID-19 …

Green stability indicating organic solvent-free HPLC determination of remdesivir in substances and pharmaceutical dosage forms

AE Ibrahim, SE Deeb, EM Abdelhalim, A Al-Harrasi… - Separations, 2021 - mdpi.com
A green liquid chromatographic method is considered in this work to minimize the
environmental impact of waste solvents. One important principle is to replace or eliminate …

Eco-friendly stability-indicating HPTLC micro-determination of the first FDA approved SARS-CoV-2 antiviral prodrug Remdesivir: Study of degradation kinetics and …

AH Abo-Gharam, DS El-Kafrawy - Sustainable chemistry and pharmacy, 2022 - Elsevier
The worldwide spread coronavirus (covid-19) pandemic caused by the severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) represents a global health crisis. The …

Green and sensitive spectrofluorimetric determination of Remdesivir, an FDA approved SARS-CoV-2 candidate antiviral; application in pharmaceutical dosage forms …

H Elmansi, AE Ibrahim, IE Mikhail, F Belal - Analytical Methods, 2021 - pubs.rsc.org
Fluorescence spectroscopy has gained much attention over the last few years. Its
advantages cover both analytical performance as well as ecological greenness. The quality …

A comparative study of HPLC and UV spectrophotometric methods for remdesivir quantification in pharmaceutical formulations

I Bulduk, E Akbel - Journal of Taibah University for Science, 2021 - Taylor & Francis
UV spectrophotometric and HPLC methods have been developed and validated for the
quantitative determination of remdesivir in pharmaceutical formulations. The HPLC analyzes …