Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Many proteins are known to promote ciliogenesis, but mechanisms that promote primary
cilia disassembly before mitosis are largely unknown. Here we identify a mechanism that …

The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-
like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with …

Accurate chromosome segregation critically depends on the formation of attachments
between microtubule polymers and each sister chromatid. The kinetochore is the …

The integration of biophysical data from multiple sources is critical for developing accurate
structural models of large multiprotein systems and their regulators. Mass spectrometry (MS) …

Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that
functions as a microtubule stabiliser. Depletion of NuSAP leads to severe mitotic defects …

Transcription at the centromere of chromosomes plays an important role in kinetochore
assembly in many eukaryotes, and noncoding RNAs contribute to activation of the mitotic …

Photobleaching event counting is a single-molecule fluorescence technique that is
increasingly being used to determine the stoichiometry of protein and RNA complexes …