Abstract Background and Objective The interstitial fluid of tissues is the effect site for
antibiotics targeting extracellular pathogens. Microdialysis studies investigating these …

Systemic antibiotic prophylaxis (SAP) is well-established in arthroplasty to prevent
periprosthetic joint infection. However, the optimal duration and dosing of SAP remain a …

Objectives Oral combination of clindamycin and rifampicin is relevant for the treatment of
staphylococcal osteoarticular infection (SOAIs). However, rifampicin induces CYP3A4 …

Background High protein binding (PB) of antibiotics has an impact on their antimicrobial
activity. It has been questioned whether in vitro PB determination can capture the dynamic …

Introduction Currently, antibiotic treatment is often a standard dosing regimen in bone and
joint infections (BJI). However, it remains unknown if exposure at the target-site is adequate …

Myofibrillar proteins are an important component of proteins. Flavor characteristics are the
key attributes of food quality. The ability of proteins to bind flavor is one of their most …

Human serum alpha-1 acid glycoprotein is an acute-phase plasma protein involved in the
binding and transport of many drugs, especially basic and lipophilic substances. It has been …

Objectives The aim of the present study was to develop a PK interaction model of
intravenous (IV) and oral clindamycin when combined with rifampicin, and to determine …

Abstract Background and Objective Exhaustive pharmacokinetic (PK) studies in paediatric
patients are unavailable for most antibiotics and feasibility of PK studies is limited by …