The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Skin pigmentation is one of the most overt human physical traits with consequences on
susceptibility to skin cancer. The variations in skin pigmentation are dependent on …

Abstract Melanocortin‐1‐receptor (MC1R) is one of the major genes that determine skin
pigmentation. MC1R variants were suggested to be associated with red hair, fair skin, and …

There has been much recent progress in our understanding of the role played by the RAS–
RAF–MEK–ERK cascade in human cancer. RAS is an oncogene and this pathway is known …

Abstract The melanocortin-1 receptor (MC1R) preferentially expressed in melanocytes is
best known as a key regulator of the synthesis of epidermal melanin pigments. Its paracrine …

Cutaneous malignant melanoma (CMM) has been increasing steadily in incidence during
the past 30 years. Recent studies have explored associations between CMM and varying …

Polymorphisms in the melanocortin 1 receptor (MC1R) gene have been associated with
increased risks of melanoma, but different approaches to study design, analysis, and …

Basal cell carcinoma (BCC) is the most common skin cancer in white populations with an
increasing incidence worldwide, thereby imposing an important public health problem. Its …

The MC1R gene is a key regulator of skin pigmentation. We aimed to evaluate the
association between MC1R variants and the risk of sporadic cutaneous melanoma (CM) …

Exposure to solar ultraviolet radiation (UV) is the main etiological factor for skin cancer,
including melanoma. Cutaneous pigmentation, particularly eumelanin, afforded by …