The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Arterial hypertension

S Brouwers, I Sudano, Y Kokubo, EM Sulaica - The Lancet, 2021 - thelancet.com
Arterial hypertension is the most important contributor to the global burden of disease;
however, disease control remains poor. Although the diagnosis of hypertension is still based …

Pathophysiology of hypertension: the mosaic theory and beyond

DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke

SB Chidambaram, AG Rathipriya, AM Mahalakshmi… - Cells, 2022 - mdpi.com
Recent research on the gut microbiome has revealed the influence of gut microbiota (GM)
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …

Immune mechanisms of hypertension

GR Drummond, A Vinh, TJ Guzik… - Nature Reviews …, 2019 - nature.com
Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Insights into salt handling and blood pressure

DH Ellison, P Welling - New England Journal of Medicine, 2021 - Mass Medical Soc
Salt Handling and Blood Pressure Salt intake is associated with blood pressure, but the
relationship is complex. This review highlights the interplay among renal salt transport, salt …

Impact of gut microbiota and microbiota-related metabolites on hyperlipidemia

X Jia, W Xu, L Zhang, X Li, R Wang… - Frontiers in Cellular and …, 2021 - frontiersin.org
Hyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been
considered as a high-risk factor and key indicator of many metabolic diseases. The gut …

Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities

Q Zeng, D Li, Y He, Y Li, Z Yang, X Zhao, Y Liu… - Scientific reports, 2019 - nature.com
The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM
markers for obesity in patients with different metabolic abnormalities and investigate their …

[HTML][HTML] Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

S Jiang, Y Shui, Y Cui, C Tang, X Wang, X Qiu, W Hu… - Redox biology, 2021 - Elsevier
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary
phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the …

Deficiency of prebiotic fiber and insufficient signaling through gut metabolite-sensing receptors leads to cardiovascular disease

DM Kaye, WA Shihata, HA Jama, K Tsyganov… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …