Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Load-bearing tissues, such as muscle and cartilage, exhibit high elasticity, high toughness
and fast recovery, but have different stiffness (with cartilage being significantly stiffer than …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Collagens are the most abundant components of the extracellular matrix and many types of
soft tissues. Elastin is another major component of certain soft tissues, such as arterial walls …

In this review, we explore different approaches for introducing bioactivity into poly (ethylene
glycol)(PEG) hydrogels. Hydrogels are excellent scaffolding materials for repairing and …

Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles
during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is …

In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Integrin α5β1 is a major fibronectin receptor critical for cell migration. Upon complex
formation, fibronectin and α5β1 undergo conformational changes. While this is key for cell …