DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

The role of histone modifications in transcription remains incompletely understood. Here, we
examine the relationship between histone modifications and transcription using …

The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …

Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …