Omics approaches unveiling the biology of human atherosclerotic plaques

X Wu, H Zhang - The American Journal of Pathology, 2024 - Elsevier
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
buildup of plaques with the accumulation and transformation of lipids, immune cells …

Cellular metabolism changes in atherosclerosis and the impact of comorbidities

Y Dai, CVC Junho, L Schieren… - Frontiers in Cell and …, 2024 - frontiersin.org
Cell activation and nutrient dysregulation are common consequences of atherosclerosis and
its preceding risk factors, such as hypertension, dyslipidemia, and diabetes. These diseases …

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

C Stroope, FS Nettersheim, B Coon, AC Finney… - Nature …, 2024 - nature.com
Accumulating evidence over the past decades has revealed an intricate relationship
between dysregulation of cellular metabolism and the progression of atherosclerotic …

Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy

Y Qian, S Xiong, L Li, Z Sun, L Zhang, W Yuan… - Cardiovascular …, 2024 - Springer
Background Diabetic macroangiopathy has been the main cause of death and disability in
diabetic patients. The mechanisms underlying smooth muscle cell transformation and …

Amino acid metabolism and atherosclerotic cardiovascular disease

SK Anand, TA Governale, X Zhang, B Razani… - The American Journal of …, 2024 - Elsevier
Despite significant advances in medical treatments and drug development, atherosclerotic
cardiovascular disease (ASCVD) remains a leading cause of death worldwide …

Molecular, metabolic, and subcellular mapping of the tumor immune microenvironment via 3D targeted and non-targeted multiplex multi-omics analyses

S Ferri-Borgogno, JK Burks, EH Seeley, TD McKee… - Cancers, 2024 - mdpi.com
Simple Summary A tumor tissue is composed of not only cancer cells but also other cell
types and microorganisms that communicate among themselves in a three-dimensional (3D) …

Role of vascular smooth muscle cell clonality in atherosclerosis

L Luo, C Fu, CF Bell, Y Wang… - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. While
many cell types contribute to the growing atherosclerotic plaque, the vascular smooth …

Spatial metabolomics and the vulnerable atherosclerotic plaque

L Luo, NJ Leeper - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
A primary goal of cardiologists is to identify and deliver targeted therapies to individuals at
risk for myocardial infarction. Although the presence and severity of atherosclerosis is a …

N-Terminal proteomics reveals distinct protein degradation patterns in different types of human atherosclerotic plaques

LG Lorentzen, K Yeung, A Zitkeviciute… - Journal of Proteome …, 2024 - ACS Publications
Atherosclerotic plaque rupture is a major cause of cardiovascular events. Plaque
destabilization is associated with extracellular matrix (ECM) modification involving proteases …

Haematometabolism rewiring in atherosclerotic cardiovascular disease

L Yvan-Charvet, T Barouillet… - Nature Reviews Cardiology, 2025 - nature.com
Atherosclerotic cardiovascular diseases are the most frequent cause of death worldwide.
The clinical complications of atherosclerosis are closely linked to the haematopoietic and …