[HTML][HTML] Innovative drying technologies for biopharmaceuticals

A Sharma, D Khamar, S Cullen, A Hayden… - International Journal of …, 2021 - Elsevier
In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …

A comprehensive review of modeling water solidification for droplet freezing applications

S Akhtar, M Xu, M Mohit, AP Sasmito - Renewable and Sustainable Energy …, 2023 - Elsevier
Various mathematical approaches undertaken to model all stages of droplet freezing are
reviewed. The literature is rife with theoretical, experimental, and numerical treatments of the …

Experimental investigation of producing ice slurry with water using opposed-nozzle impinging jet method

Y Gao, Y Ning, C Wu, M Xu, S Akhtar… - Applied Thermal …, 2023 - Elsevier
In order to improve the efficiency of producing ice slurry, an experimental device of opposed-
nozzle impinging jet was established. Deionized water of 2.5–10.5° C was jet impinged with …

Multi-scale analysis for solidification of phase change materials (PCMs): experiments and modeling

M Xu, Y Hanawa, S Akhtar, A Sakuma, J Zhang… - International Journal of …, 2023 - Elsevier
We present a multi-scale solidification framework for pure substances using laboratory
experiments and mathematical modeling. The multi-scale phenomena of solidification are …

Entrapment of air microbubbles by ice crystals during freezing exacerbates freeze-induced denaturation of proteins

HM Dao, S Sahakijpijarn, R Chrostowski… - International Journal of …, 2022 - Elsevier
Freezing techniques are an essential part of biologics manufacturing processes, yet the
formation of ice/water interfaces can impart detrimental effects on proteins. However, the …

Spray freezing: An overview of applications and modeling

M Mohit, M Xu, JC Kurnia, AS Mujumdar… - Drying …, 2024 - Taylor & Francis
Spray freezing technology finds broad applications across various industries such as food
and pharmaceutical, mining, and water treatment. The significance of spray freezing is to …

Development of a multi-stage model for freezing of a suspended binary solution droplet

M Xu, S Akhtar, M Mohit, AP Sasmito - … Journal of Heat and Mass Transfer, 2024 - Elsevier
The importance of developing spray freeze-drying technology for extending the shelf life of
biological and pharmaceutical materials has never been greater, given the increasing food …

Real-time observation of the freezing stage of the mannitol solution using high-resolution optical microscopy

L Chun, M Sha, Z Naijun, L Zhiqiang… - International Journal of …, 2023 - Elsevier
Vacuum freeze-drying has been expanding its influence in many fields, and the freezing
stage is of utmost importance for the freeze-drying process. However, the limited …

Experimental and Theoretical Studies on the Solidification of Cyclohexane on Silicon (Si) Substrate

M Mohit, M Xu, Y Hanawa, J Zhang… - Crystal Growth & …, 2024 - ACS Publications
The semiconductor industry continually seeks optimal methods to avoid nanostructure
collapse during the drying process of semiconductor device manufacturing. Despite the …

A multi-scale multi-stage model for spray freezing of binary solutions

M Mohit, M Xu, JC Kurnia, AS Mujumdar… - Drying …, 2024 - Taylor & Francis
Spray freezing has found extensive applications in drying processes, drug delivery, and
mine ventilation. The technique involves atomizing a liquefied material into a cold medium …