Modulatory role of curcumin on cobalt-induced memory deficit, hippocampal oxidative damage, astrocytosis, and Nrf2 expression

RS Oria, GE Anyanwu, EA Esom, JN Nto… - Neurotoxicity …, 2023 - Springer
Chemical overexposure is a growing environmental risk factor for many medical issues.
Cobalt toxicity from environmental, industrial, and medical exposure has previously been …

[HTML][HTML] Cobalt exposure triggers impairments in cognitive and anxiety-like behaviors, brain oxidative stress and inflammation, and hippocampo-amygdala …

RS Oria, RB Ben, UG Esomonu, PI Essien… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Objective (s): Cobalt toxicity has become a health concern in recent years, due to
overexposure resulting in neurological impairments. With a growing interest in the …

[HTML][HTML] Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats

A Akinrinde, K Adigun, O Mustapha - … Analysis, Health and …, 2023 - ncbi.nlm.nih.gov
Metal ions including cobalt (Co) ions reportedly exhibit neurotoxic and antimicrobial
properties. We hypothesized that oral exposure to Co may have implications for gut …

Protective effect of cholecalciferol against cobalt-induced neurotoxicity in rats: ZO-1/iFABP, ChAT/AchE and antioxidant pathways as potential therapeutic targets

AS Akinrinde, BO Adeoye, ES Samuel… - … Trace Element Research, 2024 - Springer
Cobalt (Co) toxicity has been reported to produce central nervous system and
gastrointestinal abnormalities. This study assessed the therapeutic effect of cholecalciferol …

Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK …

RS Oria, GE Anyanwu, JN Nto, JO Ikpa - Journal of Chemical …, 2024 - Elsevier
Curcumin, a bioactive polyphenol derived from turmeric, has been reported to have anti-
inflammatory properties. The current study investigated the anti-inflammatory effect of …

Impact of HIF1-α/TGF-β/Smad-2/Bax/Bcl2 pathways on cobalt chloride-induced cardiac and hepatorenal dysfunction

MO Kadry, HM Ali - Future Science OA, 2023 - Taylor & Francis
Background: Cobalt chloride (CoCl2) is a ferromagnetic ubiquitous trace element
extensively dispersed in the environment. Nevertheless, it may merit human hazard. Aim …

[PDF][PDF] Modulatory role of curcumin on cobalt-induced cognitive deficit, hippocampal oxidative damage, astrocytosis, and Nrf2 expression

R Oria, A Emeka, E Esom, J Nto, A Katchy, A Agu… - 2022 - academia.edu
Chemical overexposure is a growing environmental risk factor for many medical issues.
Cobalt toxicity from environmental, industrial, and medical exposure, has previously been …