Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers;
emerging evidence indicates that oncogenic β-catenin regulates several biological …

Stem cells are defined by their intrinsic capacity to self-renew and differentiate. Cancer stem
cells retain both these features but have lost homeostatic mechanisms which maintain …

Controlled regulation of cell proliferation and differentiation is essential for embryonic
development and requires the coordinated regulation of cell–cell adhesion and gene …

Deregulated Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human
cancers, yet the development of targeted therapies to disrupt the resulting aberrant …

The canonical Wnt pathway plays critical roles in embryonic development, stem cell growth,
and tumorigenesis. Stimulation of the Wnt pathway leads to the association of β-catenin with …

Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew
and are highly tumorigenic and chemoresistant. While genetic mutations associated with …

Several components of the Wnt signaling cascade have been shown to function either as
tumor suppressor proteins or as oncogenes in multiple human cancers, underscoring the …

We have previously observed that Wnt signaling activates a fibrogenic program in adult
muscle stem cells, called satellite cells, during aging. We genetically labeled satellite cells in …