Best practices for analysing microbiomes

R Knight, A Vrbanac, BC Taylor, A Aksenov… - Nature Reviews …, 2018 - nature.com
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

Analysis of microbial compositions: a review of normalization and differential abundance analysis

H Lin, SD Peddada - NPJ biofilms and microbiomes, 2020 - nature.com
Increasingly, researchers are discovering associations between microbiome and a wide
range of human diseases such as obesity, inflammatory bowel diseases, HIV, and so on …

Establishing microbial composition measurement standards with reference frames

JT Morton, C Marotz, A Washburne, J Silverman… - Nature …, 2019 - nature.com
Differential abundance analysis is controversial throughout microbiome research. Gold
standard approaches require laborious measurements of total microbial load, or absolute …

Plant microbiota dysbiosis and the Anna Karenina Principle

G Arnault, C Mony, P Vandenkoornhuyse - Trends in Plant Science, 2023 - cell.com
Microorganisms are associated with all plants, recently leading to the hologenome concept.
We reviewed the assembly processes of plant microbiota and analyzed its structure during …

Genesis and Gappa: processing, analyzing and visualizing phylogenetic (placement) data

L Czech, P Barbera, A Stamatakis - Bioinformatics, 2020 - academic.oup.com
We present genesis, a library for working with phylogenetic data, and gappa, an
accompanying command-line tool for conducting typical analyses on such data. The tools …

Understanding sequencing data as compositions: an outlook and review

TP Quinn, I Erb, MF Richardson, TM Crowley - Bioinformatics, 2018 - academic.oup.com
Motivation Although seldom acknowledged explicitly, count data generated by sequencing
platforms exist as compositions for which the abundance of each component (eg gene or …

A field guide for the compositional analysis of any-omics data

TP Quinn, I Erb, G Gloor, C Notredame… - …, 2019 - academic.oup.com
Background Next-generation sequencing (NGS) has made it possible to determine the
sequence and relative abundance of all nucleotides in a biological or environmental …

Balances: a new perspective for microbiome analysis

J Rivera-Pinto, JJ Egozcue, V Pawlowsky-Glahn… - …, 2018 - Am Soc Microbiol
High-throughput sequencing technologies have revolutionized microbiome research by
allowing the relative quantification of microbiome composition and function in different …

The microbiome stress project: toward a global meta-analysis of environmental stressors and their effects on microbial communities

JD Rocca, M Simonin, JR Blaszczak… - Frontiers in …, 2019 - frontiersin.org
Microbial community structure is highly sensitive to natural (eg, drought, temperature, fire)
and anthropogenic (eg, heavy metal exposure, land-use change) stressors. However …

Chemically informed analyses of metabolomics mass spectrometry data with Qemistree

A Tripathi, Y Vázquez-Baeza, JM Gauglitz… - Nature chemical …, 2021 - nature.com
Untargeted mass spectrometry is employed to detect small molecules in complex
biospecimens, generating data that are difficult to interpret. We developed Qemistree, a data …