A 9‐pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum
W Tang, AT Deshmukh, C Haringa… - Biotechnology and …, 2017 - Wiley Online Library
ABSTRACT A powerful approach for the optimization of industrial bioprocesses is to perform
detailed simulations integrating large‐scale computational fluid dynamics (CFD) and cellular …
detailed simulations integrating large‐scale computational fluid dynamics (CFD) and cellular …
Influence of oxygen concentration on the metabolism of Penicillium chrysogenum
A Janoska, JJ Verheijen, W Tang, Q Lee… - Engineering in Life …, 2023 - Wiley Online Library
In large‐scale bioreactors, there is often insufficient mixing and as a consequence, cells
experience uneven substrate and oxygen levels that influence product formation. In this …
experience uneven substrate and oxygen levels that influence product formation. In this …
In vivo kinetic analysis of the penicillin biosynthesis pathway using PAA stimulus response experiments
AT Deshmukh, PJT Verheijen, RM Seifar… - Metabolic …, 2015 - Elsevier
In this study we combined experimentation with mathematical modeling to unravel the in
vivo kinetic properties of the enzymes and transporters of the penicillin biosynthesis pathway …
vivo kinetic properties of the enzymes and transporters of the penicillin biosynthesis pathway …
Comparative fluxome and metabolome analysis of formate as an auxiliary substrate for penicillin production in Glucose‐Limited cultivation of Penicillium chrysogenum
G Wang, X Wang, T Wang, W van Gulik… - Biotechnology …, 2019 - Wiley Online Library
During glucose‐limited growth, a substantial input of adenosine triphosphate (ATP) is
required for the production of β‐lactams by the filamentous fungus Penicillium chrysogenum …
required for the production of β‐lactams by the filamentous fungus Penicillium chrysogenum …
[引用][C] Elucidation and modeling of the in-vivo kinetics of enzymes and membrane transporters associated with β-lactam and non-ribosomal peptide production in …
AT Deshmukh - 2013