Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …