The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Y Shi, JB Liu, J Deng, DZ Zou, JJ Wu, YH Cao, J Yin… - Hereditas, 2021 - Springer
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide due to its high degree of malignancy, high incidence, and low survival rate …

Cancer-associated fibroblasts influence the biological properties of malignant tumours via paracrine secretion and exosome production

M Vokurka, L Lacina, J Brábek, M Kolář, YZ Ng… - International Journal of …, 2022 - mdpi.com
Cancer-associated fibroblasts (CAFs) are an essential component of the tumour
microenvironment. They represent a heterogeneous group of cells that are under the control …

Shared and divergent epigenetic mechanisms in cachexia and sarcopenia

L Yedigaryan, M Gatti, V Marini, T Maraldi… - Cells, 2022 - mdpi.com
Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major
causes of mortality and disability. Cachexia represents a complex multi-organ syndrome …

Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss

S Sun, Z Wang, F Yao, K Sun, Z Li… - Human Molecular …, 2023 - academic.oup.com
Cachexia occurrence and development are associated with loss of white adipose tissues,
which may be involved with cancer-derived exosomes. This study attempted to characterize …

Cancer cachexia: signaling and transcriptional regulation of muscle catabolic genes

VK Rao, D Das, R Taneja - Cancers, 2022 - mdpi.com
Simple Summary An uncontrollable loss in the skeletal muscle of cancer patients which
leads to a significant reduction in body weight is clinically referred to as cancer cachexia …

Molecular Mechanisms of Cachexia: A Review

M Neshan, DI Tsilimigras, X Han, H Zhu, TM Pawlik - Cells, 2024 - mdpi.com
Cachexia is a condition characterized by substantial loss of body weight resulting from the
depletion of skeletal muscle and adipose tissue. A considerable fraction of patients with …

Decreased mir-497-5p suppresses il-6 induced atrophy in muscle cells

PP Freire, SS Cury, LO Lopes, GJ Fernandez, J Liu… - Cells, 2021 - mdpi.com
Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in
cancer cachexia. The control of gene expression by microRNAs (miRNAs) in muscle wasting …

Three Pathways of Cancer Cachexia: inflammation, changes in adipose tissue and loss of muscle Mass—The role of miRNAs

I Homa-Mlak, D Pigoń-Zając, P Wawrejko… - Journal of Personalized …, 2022 - mdpi.com
According to the World Health Organization, in 2018, cancers, along with over 18 million
new cases and over 9.5 million deaths remained one of the main causes of mortality …

Low miR 511-5p Expression as a Potential Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation …

M Mazurek, R Mlak, I Homa-Mlak, T Powrózek… - Journal of Clinical …, 2022 - mdpi.com
Nutritional deficiencies, including malnutrition and its irreversible type cachexia, are often
observed in patients with head and neck cancer (HNC). Among the various factors …

Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma

YC Yu, A Ahmed, HC Lai, WC Cheng, JC Yang… - Frontiers in …, 2022 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of solid tumors,
associated with a high prevalence of cachexia (~ 80%). PDAC-derived cachexia (PDAC-CC) …