Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Clinical application of bone marrow mesenchymal stem/stromal cells to repair skeletal tissue

A Arthur, S Gronthos - International journal of molecular sciences, 2020 - mdpi.com
There has been an escalation in reports over the last decade examining the efficacy of bone
marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and …

The development of molecular biology of osteoporosis

Y Gao, S Patil, J Jia - International journal of molecular sciences, 2021 - mdpi.com
Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

Molecular-based treatment strategies for osteoporosis: a literature review

Y Ukon, T Makino, J Kodama, H Tsukazaki… - International journal of …, 2019 - mdpi.com
Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-
resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators …

Niches for skeletal stem cells of mesenchymal origin

AD Kurenkova, EV Medvedeva, PT Newton… - Frontiers in cell and …, 2020 - frontiersin.org
With very few exceptions, all adult tissues in mammals are maintained and can be renewed
by stem cells that self-renew and generate the committed progeny required. These functions …

Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia

K Woods, B Guezguez - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are a heterogenous cell population found in a wide
range of tissues in the body, known for their nutrient-producing and immunomodulatory …

Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic …

AR Reis, RKF Santos, CB Dos Santos… - Nutrition, 2023 - Elsevier
Menopause and vitamin D deficiency increase bone reabsorption and bone fracture risk in
women in postmenopause, and vitamin D supplementation may improve bone health and …

Graphene oxide/RhPTH (1-34)/polylactide composite nanofibrous scaffold for bone tissue engineering

F Fei, H Yao, Y Wang, J Wei - International Journal of Molecular Sciences, 2023 - mdpi.com
Polylactide (PLA) is one of the most promising polymers that has been widely used for the
repair of damaged tissues due to its biocompatibility and biodegradability. PLA composites …

Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis

Z Xiao, J Baudry, L Cao, J Huang… - The Journal of …, 2018 - Am Soc Clin Investig
The molecular mechanisms that transduce the osteoblast response to physical forces in the
bone microenvironment are poorly understood. Here, we used genetic and pharmacological …

Effects of PTH and PTH hypersecretion on bone: a clinical perspective

L Rejnmark, H Ejlsmark-Svensson - Current osteoporosis reports, 2020 - Springer
Abstract Purpose of Review Hyperparathyroidism may be due to an autonomous
hypersecretion of parathyroid hormone (PTH) or occurs in response to a number of …