Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo, C Garland - Pharmacological reviews, 2021 - Elsevier
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions
SH Francis, MA Blount, JD Corbin - Physiological reviews, 2011 - journals.physiology.org
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
M Conti, J Beavo - Annu. Rev. Biochem., 2007 - annualreviews.org
Although cyclic nucleotide phosphodiesterases (PDEs) were described soon after the
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
discovery of cAMP, their complexity and functions in signaling is only recently beginning to …
[HTML][HTML] FGF1 and insulin control lipolysis by convergent pathways
Inexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP)
are hallmarks of type 2 diabetes. Previously, we showed that peripheral delivery of …
are hallmarks of type 2 diabetes. Previously, we showed that peripheral delivery of …
Overview of PDEs and their regulation
K Omori, J Kotera - Circulation research, 2007 - Am Heart Assoc
Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key
physiological events in the cardiovascular system. These events are regulated by second …
physiological events in the cardiovascular system. These events are regulated by second …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
AKAP signalling complexes: focal points in space and time
Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
Clinical and molecular genetics of the phosphodiesterases (PDEs)
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
MD Houslay, DR Adams - Biochemical Journal, 2003 - portlandpress.com
cAMP is a second messenger that controls many key cellular functions. The only way to
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …
Keynote review: phosphodiesterase-4 as a therapeutic target
MD Houslay, P Schafer, KYJ Zhang - Drug discovery today, 2005 - Elsevier
Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …