Uncovering the Hidden Credentials of Brucella Virulence

RM Roop, IS Barton, D Hopersberger… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Immune Response to Mucosal Brucella Infection

R López-Santiago, AB Sánchez-Argáez… - Frontiers in …, 2019 - frontiersin.org
Brucellosis is one of the most prevalent bacterial zoonosis of worldwide distribution. The
disease is caused by Brucella spp., facultative intracellular pathogens. Brucellosis in …

Bacillus Calmette-Guérin–Trained Macrophages Elicit a Protective Inflammatory Response against the Pathogenic Bacteria Brucella abortus

ACVSC de Araujo, NMGP de Queiroz… - The Journal of …, 2023 - journals.aai.org
Abstract The bacillus Calmette-Guérin (BCG) can elicit enhanced innate immune responses
against a wide range of infections, known as trained immunity. Brucella abortus is the …

Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella

J Sedzicki, D Ni, F Lehmann, N Wu, R Zenobi… - Nature Structural & …, 2022 - nature.com
Polysaccharides play critical roles in bacteria, including the formation of protective capsules
and biofilms and establishing specific host cell interactions. Their transport across …

Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

J Sedzicki, D Ni, F Lehmann, H Stahlberg… - Nature …, 2024 - nature.com
The synthesis of complex sugars is a key aspect of microbial biology. Cyclic β-1, 2-glucan
(CβG) is a circular polysaccharide critical for host interactions of many bacteria, including …

[PDF][PDF] Immune response and recent advances in diagnosis and control of brucellosis

A Elrashedy, M Gaafar, W Mousa, M Nayel… - Ger. J. Vet …, 2022 - researchgate.net
Brucellosis is a zoonotic disease that has serious animal welfare and economic
consequences worldwide. In mammals, this stealthy intracellular pathogen causes abortion …

Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties

S Mena-Bueno, I Poveda-Urkixo, O Irazoki… - Frontiers in …, 2022 - frontiersin.org
The lipopolysaccharide (LPS) O-polysaccharide (O-PS) is the main virulence factor in
Brucella. After synthesis in the cytoplasmic membrane, O-PS is exported to the periplasm by …

TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus

MT Gomes, PC Campos, GS Pereira… - Journal of Leucocyte …, 2016 - academic.oup.com
Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis
of worldwide occurrence, leading to undulant fever in humans and abortion in domestic …

Brucella abortus cell cycle and infection are coordinated

X De Bolle, S Crosson, JY Matroule, JJ Letesson - Trends in microbiology, 2015 - cell.com
Brucellae are facultative intracellular pathogens. The recent development of methods and
genetically engineered strains allowed the description of cell-cycle progression of Brucella …

β-1, 2-Glucans and associated enzymes

M Nakajima - Biologia, 2023 - Springer
Sugar chains are biopolymers that play various important roles for organisms, and their
structures are complex and diverse. Enzymes acting on sugar chains have undergone a …