Conceptualizing mental disorders as deviations from normative functioning
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …
heterogeneous biology underlying psychiatric disorders at the level of the individual …
Psychosis superspectrum I: Nosology, etiology, and lifespan development
This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
A canonical trajectory of executive function maturation from adolescence to adulthood
Theories of human neurobehavioral development suggest executive functions mature from
childhood through adolescence, underlying adolescent risk-taking and the emergence of …
childhood through adolescence, underlying adolescent risk-taking and the emergence of …
Linked dimensions of psychopathology and connectivity in functional brain networks
Neurobiological abnormalities associated with psychiatric disorders do not map well to
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level …
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level …
Modular segregation of structural brain networks supports the development of executive function in youth
The human brain is organized into large-scale functional modules that have been shown to
evolve in childhood and adolescence. However, it remains unknown whether the underlying …
evolve in childhood and adolescence. However, it remains unknown whether the underlying …
Burden of environmental adversity associated with psychopathology, maturation, and brain behavior parameters in youths
Importance Low socioeconomic status (L-SES) and the experience of traumatic stressful
events (TSEs) are environmental factors implicated in behavioral deficits, abnormalities in …
events (TSEs) are environmental factors implicated in behavioral deficits, abnormalities in …
The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth
Abstract The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child
development that combines neuroimaging, diverse clinical and cognitive phenotypes, and …
development that combines neuroimaging, diverse clinical and cognitive phenotypes, and …
Common and dissociable mechanisms of executive system dysfunction across psychiatric disorders in youth
Objective: Disruption of executive function is present in many neuropsychiatric disorders.
However, determining the specificity of executive dysfunction across these disorders is …
However, determining the specificity of executive dysfunction across these disorders is …