Role of the sclera in the development and pathological complications of myopia

NA McBrien, A Gentle - Progress in retinal and eye research, 2003 - Elsevier
Myopia is one of the most prevalent ocular conditions and is the result of a mismatch
between the power of the eye and axial length of the eye. As a result images of distant …

Biomechanics of the sclera in myopia: extracellular and cellular factors

NA McBrien, AI Jobling, A Gentle - Optometry and vision science, 2009 - journals.lww.com
Purpose. Excessive axial elongation of the eye is the principal structural cause of myopia.
The increase in eye size results from active remodelling of the sclera, producing a …

Emmetropization and nonmyopic eye growth

J Rozema, S Dankert, R Iribarren - Survey of Ophthalmology, 2023 - Elsevier
Most eyes start with a hypermetropic refractive error at birth, but the growth rates of the
ocular components, guided by visual cues, will slow in such a way that this refractive error …

Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia

A Gentle, Y Liu, JE Martin, GL Conti… - Journal of Biological …, 2003 - ASBMB
The development of high myopia is associated with reduced scleral collagen accumulation,
scleral thinning, and loss of scleral tissue, in both humans and animal models. Reduced …

Pathologic myopia: where are we now?

Y Tano - American journal of ophthalmology, 2002 - Elsevier
PURPOSE: To describe current concepts and available treatments for pathologic myopia.
DESIGN: Review of experimental and clinical studies. METHODS: The demography, natural …

The tree shrews: adjuncts and alternatives to primates as models for biomedical research

J Cao, EB Yang, JJ Su, Y Li… - Journal of medical …, 2003 - Wiley Online Library
The tree shrews are non‐rodent, primate‐like, small animals. There is increasing interest in
using them to establish animal models for medical and biological research. This review …

Regulation of scleral metabolism in myopia and the role of transforming growth factor-beta

NA McBrien - Experimental eye research, 2013 - Elsevier
Myopia is one of the most prevalent ocular conditions and is the result of a mismatch
between the power of the eye and axial length of the eye. In the vast majority of cases the …

[HTML][HTML] Insight into the molecular genetics of myopia

J Li, Q Zhang - Molecular vision, 2017 - ncbi.nlm.nih.gov
Myopia is the most common cause of visual impairment worldwide. Genetic and
environmental factors contribute to the development of myopia. Studies on the molecular …

The biological basis of myopic refractive error

IG Morgan - Clinical and Experimental Optometry, 2003 - Wiley Online Library
Myopia is among the most common refractive errors and is associated with the greatest risk
of pathological outcomes. Most animals, including humans, are born with hyperopic errors …

[HTML][HTML] The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery

JT Siegwart, TT Norton - Investigative ophthalmology & visual …, 2002 - arvojournals.org
purpose. In tree shrews, visual form deprivation produces increased axial elongation of the
deprived eye and a myopic shift in refractive state. A change in scleral extensibility (creep …