Update on treatments for anxiety-related disorders

HJ Lee, MB Stein - Current opinion in psychiatry, 2023 - journals.lww.com
Pharmacotherapy of anxiety disorders is expanding to novel products. Despite trying other
psychological therapies for anxiety disorders, most therapies were comparable to but not …

Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020

EI Kopra, JA Ferris, AR Winstock… - Journal of …, 2023 - journals.sagepub.com
Background: Growing numbers of people are using psychedelics for personal
psychotherapy outside clinical settings, but research on such use is scarce. Aims: This study …

[HTML][HTML] Therapeutic role of psilocybin and 3, 4-methylenedioxymethamphetamine in trauma: A literature review

LN Fonseka, BK Woo - World Journal of Psychiatry, 2023 - ncbi.nlm.nih.gov
Abstract With the Food and Drug Administration designation in 2017 of 3, 4-
methylenedioxymethamphetamine (MDMA) as a breakthrough therapy in post-traumatic …

Psilocybin facilitates fear extinction: importance of dose, context, and serotonin receptors

SC Woodburn, CM Levitt, AM Koester… - ACS Chemical …, 2024 - ACS Publications
A variety of classic psychedelics and MDMA have been shown to enhance fear extinction in
rodent models. This has translational significance because a standard treatment for post …

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

Y Du, Y Li, X Zhao, Y Yao, B Wang, L Zhang… - Chinese Medical …, 2023 - mednexus.org
Background: Posttraumatic stress disorder (PTSD) and depression are highly comorbid.
Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity …

The Psychedelic Future of Post-Traumatic Stress Disorder Treatment

TG Zaretsky, KM Jagodnik, R Barsic… - Current …, 2024 - ingentaconnect.com
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following
exposure to a traumatic experience. An estimated 12 million US adults are presently affected …

Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies

M Sabé, A Sulstarova, A Glangetas, M De Pieri… - Molecular …, 2024 - nature.com
Background Persons with schizophrenia are excluded from psychedelic-assisted therapy
due to concerns about the risk of triggering or worsening psychosis. However, there is …

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short-but not long-term in a rat model of posttraumatic stress disorder.

Z Ghofrani-Jahromi, S Nouri-Darehno… - Behavioral …, 2024 - psycnet.apa.org
Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate
potency whose principal active compounds are psilocybin and psilocin. Recent studies have …

A narrative exploration of psilocybin's potential in mental health

H Min, SY Park, J Park, S Na, HS Lee, T Kim… - Frontiers in …, 2024 - frontiersin.org
Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic
potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin …

Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortex

D Zhou, H Schuler, V Cvetkovska, J Meccia… - bioRxiv, 2025 - biorxiv.org
The ever-increasing burden of psychiatric disorders and limitations of current treatments
have fueled enormous interest in the therapeutic potential of psychedelics. Yet how …