Insulin sensitizers in 2023: Lessons learned and new avenues for investigation
JR Colca, SP Tanis, RF Kletzien… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction 'Insulin sensitizers' derived discoveries of the Takeda Company in 1970s.
Pioglitazone remains the best in class with beneficial pleiotropic pharmacology, although …
Pioglitazone remains the best in class with beneficial pleiotropic pharmacology, although …
Blocking Mitochondrial Pyruvate Transport Alters Corneal Myofibroblast Phenotype: A New Target for Treating Fibrosis
KI Jeon, A Kumar, CL Callan… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: The purpose of this study was to critically test the hypothesis that mitochondrial
pyruvate carrier (MPC) function is essential for maintenance of the corneal myofibroblast …
pyruvate carrier (MPC) function is essential for maintenance of the corneal myofibroblast …
[HTML][HTML] Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis
Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or
infection. However, their persistent deposition of disorganized extracellular matrix can also …
infection. However, their persistent deposition of disorganized extracellular matrix can also …
The Therapeutic Potential of Targeting Hepatic MCT1 in Non-Alcoholic Steatohepatitis
K Min - 2023 - repository.escholarship.umassmed …
Emerging evidence supports substrate overload to the liver as an initial driver of non-
alcoholic steatohepatitis (NASH) progression. Metabolic disease patients have increased …
alcoholic steatohepatitis (NASH) progression. Metabolic disease patients have increased …