Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The precision and complexity of intron removal during pre-mRNA splicing still amazes even
26 years after the discovery that the coding information of metazoan genes is interrupted by …

Summary in humans, germiine mutations of the WT-7 tumor suppressor gene are associated
with both Wiims' tumors and urogenital malformations. To develop a model system for the …

The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Human pluripotent stem cells (hPSCs) can generate a diversity of cell types, but few
methods have been developed to derive cells of the kidney lineage. Here, we report a highly …

THE kidney has been widely exploited as a model system for the study of tissue inductions
regulating vertebrate organogenesis1, 2. Kidney development is initiated by the ingrowth of …

Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …

Relapse remains a leading cause of death after allogeneic hematopoietic cell
transplantation (HCT) for patients with high-risk leukemias. The potentially beneficial donor …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …

Bone morphogenetic proteins (BMPs) are multifunctional growth factors originally identified
by their ability to induce ectopic bone formation. To investigate the function of one of the …