Objective To summarize studies highlighting recent advances in rhinitis-related research in
the past 2 years. Data Sources Original research articles were procured and examined from …

The aim of this study is to review advances in basic and clinical allergic rhinitis (AR)
research over the past decade that have been conducted using controlled allergen …

Background Pollen variation can affect field study data quality. Nasal allergen challenge
(NAC) is considered the gold standard for evaluating allergic rhinitis, while environmental …

Background There is limited knowledge on how local cytokine secretion patterns after nasal
allergen challenge correlate with clinical symptoms especially with regard to the “late …

Background Similar immune responses in the nasal and bronchial mucosa implies that
nasal allergen challenge (NAC) is a suitable early phase experimental model for drug …

Abstract Rationale The Environmental Exposure Unit (EEU), a controlled allergen exposure
model of allergic rhinitis (AR), has traditionally utilized ragweed pollen. We sought to …

Background Previous studies have defined clinical phenotypes of allergic rhinitis (AR) after
allergen exposure using the time course of the total nasal symptom score (TNSS). Objective …

Abstract Background The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada
is a controlled allergen challenge facility (CACF) that has been previously clinically …

Background There are few direct data concerning symptom dynamics of allergic
conjunctivitis (AC) in an allergen challenge chamber (ACC). Objective To determine the AC …

Abstract Rationale The Environmental Exposure Unit (EEU), a controlled allergen exposure
model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to …