Fructose 1, 6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the
fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and …

Cellular processes often depend on interactions between proteins and the formation of
macromolecular complexes. The impairment of such interactions can lead to deregulation of …

Giardia duodenalis (syn. G. lamblia, G. intestinalis) is a flagellated protozoan, member of the
order Diplomonadidae, that parasitizes the upper part of the small intestine of mammals …

Site-selective chemical conjugation of synthetic molecules to proteins expands their
functional and therapeutic capacity. Current protein modification methods, based on …

Designing catalysts that achieve the rates and selectivities of natural enzymes is a long-
standing goal in protein chemistry. Here, we show that an ultrahigh-throughput droplet …

Diarrheal diseases are among the leading causes of morbidity and mortality in the world,
particularly among young children. A limited number of infectious agents account for most of …

The search for antituberculosis drugs active against persistent bacilli has led to our interest
in metallodependent class II fructose-1, 6-bisphosphate aldolase (FBA-tb), a key enzyme of …

Abstract The Seattle Structural Genomics Center for Infectious Disease (SSGCID) focuses
on the structure elucidation of potential drug targets from class A, B, and C infectious …

Elucidating the structures and stabilities of proteins and their complexes is paramount to
understanding their biological functions in cellular processes. Native mass spectrometry …

Class II fructose 1, 6-bisphosphate aldolase (FBA) is an enzyme critical for bacterial, fungal,
and protozoan glycolysis/gluconeogenesis. Importantly, humans lack this type of aldolase …