Gene stacking in transgenic plants–the challenge for 21st century plant biotechnology

C Halpin - Plant biotechnology journal, 2005 - Wiley Online Library
One of the major technical hurdles impeding the advance of plant genetic engineering and
biotechnology is the fact that the expression or manipulation of multiple genes in plants is …

Development of 2A peptide-based strategies in the design of multicistronic vectors

AL Szymczak, DAA Vignali - Expert opinion on biological therapy, 2005 - Taylor & Francis
As science progresses in its understanding of diseases and their treatment, advances have
been made in the biotechnology used in disease therapy. Most gene therapy approaches …

Quantitative profiling of initiating ribosomes in vivo

X Gao, J Wan, B Liu, M Ma, B Shen, SB Qian - Nature methods, 2015 - nature.com
Cells have evolved exquisite mechanisms to fine-tune the rate of protein synthesis in
response to stress. Systemic mapping of start-codon positions and precise measurement of …

Non-canonical translation initiation mechanisms employed by eukaryotic viral mRNAs

II Sorokin, KS Vassilenko, IM Terenin, NO Kalinina… - Biochemistry …, 2021 - Springer
Viruses exploit the translation machinery of an infected cell to synthesize their proteins.
Therefore, viral mRNAs have to compete for ribosomes and translation factors with cellular …

Enteroviruses: classification, diseases they cause, and approaches to development of antiviral drugs

OS Nikonov, ES Chernykh, MB Garber… - Biochemistry (moscow …, 2017 - Springer
The genus Enterovirus combines a portion of small (+) ssRNA-containing viruses and is
divided into 10 species of true enteroviruses and three species of rhinoviruses. These …

[HTML][HTML] Translational control in positive strand RNA plant viruses

TW Dreher, WA Miller - Virology, 2006 - Elsevier
The great variety of genome organizations means that most plant positive strand viral RNAs
differ from the standard 5′-cap/3′-poly (A) structure of eukaryotic mRNAs. The cap and …

Non-canonical translation in plant RNA viruses

M Miras, WA Miller, V Truniger, MA Aranda - Frontiers in plant science, 2017 - frontiersin.org
Viral protein synthesis is completely dependent upon the host cell's translational machinery.
Canonical translation of host mRNAs depends on structural elements such as the 5′ cap …

Overproduction of recombinant proteins in plants

E Egelkrout, V Rajan, JA Howard - Plant science, 2012 - Elsevier
Recombinant protein production in microbial hosts and animal cell cultures has
revolutionized the pharmaceutical and industrial enzyme industries. Plants as alternative …

Translation machinery: the basis of translational control

S Yuan, G Zhou, G Xu - Journal of Genetics and Genomics, 2023 - Elsevier
Messenger RNA (mRNA) translation consists of initiation, elongation, termination, and
ribosome recycling, carried out by the translation machinery, primarily including tRNAs …

Translational control of retroviruses

L Balvay, ML Lastra, B Sargueil, JL Darlix… - Nature Reviews …, 2007 - nature.com
All replication-competent retroviruses contain three main reading frames, gag, pol and env,
which are used for the synthesis of structural proteins, enzymes and envelope proteins …