Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …

Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in
different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of
cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to …

Cancer cells can evade immune surveillance through the expression of inhibitory ligands
that bind their cognate receptors on immune effector cells. Expression of programmed death …

Progressive accrual of senescent cells in aging and chronic diseases is associated with
detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia …

Layered double hydroxide (LDH) nanostructures and related nanocomposites have
attracted significant interest in biomedical applications including cancer therapy, bioimaging …

Background Ageing is a highly complex process marked by a temporal cascade of events,
which promote alterations in the normal functioning of an individual organism. The triggers …