Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Although synthesized nanotherapeutics (NTs) are attractive for the oral treatment of colon
diseases, their clinical translations are constrained by the unsatisfactory therapeutic …

The requirement for the favorable therapeutics against ulcerative colitis (UC) is that anti-
inflammatory drugs can be specifically internalized by macrophages and subsequently be …

In hypertrophic hearts, autophagic flux insufficiency is recognized as a key pathology
leading to maladaptive cardiac remodeling and heart failure. This study aimed to illuminate …

Chronic and progressive inflammation is the key pathogenesis of inflammatory bowel
disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), which involve …

Disruption of the gut barrier results in severe clinical outcomes with no specific treatment.
Metabolic disorders and destruction of enterocytes play key roles in gut barrier dysfunction …

Ulcerative colitis (UC) is one type of inflammatory bowel disease (IBD) and lactoferrin (LF) is
a promising protein drug to treat UC. However, targeted LF delivery to optimize …

A sedentary lifestyle and obesity are important risk factors for severe COVID-19
complications and death [1, 2]. Excessive adipose tissue (AT) might contribute to more …

Irisin is a novel myokine and adipokine that has gained much attention recently due to its
mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor …