Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Assay devices designed for these applications offer improvements to existing methods or
provide fundamentally new strategies. Both mature methods and novel techniques have …

Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …

Microfluidic devices offer great advantages in integrating sample processes, minimizing
sample and reagent volumes, and increasing analysis speed, while mass spectrometry …

Mutations in the BCR-ABL1 kinase domain are an established mechanism of tyrosine kinase
inhibitor (TKI) resistance in Philadelphia chromosome-positive leukemia, but fail to explain …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

Microfluidic technology has shown advantages of low sample consumption, reduced
analysis time, high throughput, and potential for integration and automation. Coupling …

Virtually all protein functions in the cell, including pathogenic processes, require coordinated
motion of atoms or domains, ie, conformational dynamics. Understanding protein dynamics …

Life at the molecular level is a dynamic world, where the key players─ proteins,
oligonucleotides, lipids, and carbohydrates─ are in a perpetual state of structural flux …