Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

Circular dichroism (CD) spectroscopy is a widely used method to study the protein
secondary structure. However, for decades, the general opinion was that the correct …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve
trauma or disease. A central mechanism is the reduced expression of the potassium chloride …

Coupling of size-exclusion chromatography with biological solution small-angle X-ray
scattering (SEC-SAXS) on dedicated synchrotron beamlines enables structural analysis of …

Glycosaminoglycans (GAGs) are long and unbranched polysaccharides that are abundant
in the extracellular matrix and basement membrane of multicellular organisms. These linear …

Glycosaminoglycans (GAGs) constitute a considerable fraction of the glycoconjugates found
on cellular membranes and in the extracellular matrix of virtually all mammalian tissues. The …

The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition
to protein fibrils, amyloid plaques also contain non-proteinaceous components, including …

Amyloid deposits of WT apolipoprotein AI (apoA-I), the main protein component of high-
density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to …

Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in
biological tissue during the progression of several human disorders, including Alzheimer's …