Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

Many signaling pathways are dysregulated in cancer cells and the host tumor
microenvironment. Aberrant receptor tyrosine kinase (RTK) pathways promote cancer …

It has been over three decades since the hepatocyte growth factor (HGF) ligand and its
receptor MET proto-oncogene (MET) pathway was established as promoting cancer growth …

Dysregulated activation of the MET tyrosine kinase receptor is implicated in the development
of solid tumors and can arise through several mechanisms, including gene amplification …

MET has been considered as a promising drug target for the treatment of MET-dependent
diseases, particularly non-small cell lung cancer (NSCLC). Small molecule MET inhibitors …

The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …

Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …

Abstract Treatment of advanced non-small cell lung cancer (NSCLC) has radically improved
in the last years due to development and clinical approval of highly effective agents …

Simple Summary Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor
(MET) signaling plays an important role in the metastatic formation and therapeutic …