Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

The second messenger cyclic AMP (cAMP) can either stimulate or inhibit programmed cell
death (apoptosis). Here, we review examples of cell types that show pro‐apoptotic or anti …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Inflammation, cell adhesion to vascular endothelium, and endothelial injury contribute to
sickle cell anemia (SCA) vaso-occlusion. Although alterations in inflammatory cytokines and …

Sickle cell disease is an inherited disorder of hemoglobin (Hb) synthesis, caused by a single
nucleotide substitution (GTG> GAG) at the sixth codon of the β-globin gene, leading to the …

Granulocyte colony-stimulating factor (G-CSF) is used commonly in an attempt to reduce the
duration of neutropenia and hospitalization in patients undergoing chemotherapy and to …

PDE4 inhibition is effective at resolving neutrophilic inflammation after LPS-challenge by
promoting caspase-3-dependent apoptosis of inflammatory cells in the pleural cavity. PDE4 …

Objective: To summarize recently published data on the pathophysiology, diagnosis and
treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary …

Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in
sickle cell disease. Since nitric oxide bioavailability is decreased in sickle cell disease and …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …