The development of novel cancer therapeutics is often plagued by discrepancies between
drug efficacies obtained in preclinical studies and outcomes of clinical trials. The …

The extracellular microenvironment plays a significant role in controlling cellular behavior.
Identification of appropriate biomaterials that support cellular attachment, proliferation and …

The efficacy of potential anticancer drugs during preclinical development is generally tested
in vitro using cancer cells grown in monolayer; however, a significant discrepancy in their …

Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis
and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular …

Acute lymphoblastic leukemia (ALL) initiates and progresses in the bone marrow, and as
such, the marrow microenvironment is a critical regulatory component in development of this …

Cell therapies have been used to regenerate the heart by direct myocardial delivery, by
coronary infusion and by surface attached scaffolds. Multipotent mesenchymal stem cells …

The fabrication of biodegradable 3‐D scaffolds enriched with multipotent stem cells seems
to be a promising strategy for the repair of irreversibly injured tissues. The fine mechanisms …

There is an increasing need for an effective in vitro model that can resemble the 3-D nature
of tumor microenvironments. In this work, a 3-D bacterial cellulose (BC) scaffold with …

Tissue engineering and the use of nanofibrous biomaterial scaffolds offer a unique
perspective for studying cancer development in vitro. Current in vitro models of …

The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade
to the surrounding and far tissues of the body is the leading cause of mortality in cancer …