Alzheimer's disease: clinical trials and drug development
F Mangialasche, A Solomon, B Winblad… - The Lancet …, 2010 - thelancet.com
Alzheimer's disease is the most common cause of dementia in elderly people. Research into
Alzheimer's disease therapy has been at least partly successful in terms of developing …
Alzheimer's disease therapy has been at least partly successful in terms of developing …
Multi-target-directed ligands to combat neurodegenerative diseases
Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …
decades. As a consequence, drug discovery has gradually shifted from an entirely …
Polyphenols: multipotent therapeutic agents in neurodegenerative diseases
KS Bhullar, HPV Rupasinghe - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells
K Jiménez-Aliaga, P Bermejo-Bescós, J Benedí… - Life sciences, 2011 - Elsevier
AIMS: Quercetin and rutin have been reported to exert numerous pharmacological activities,
such as free-radical scavenging, effects on immune and inflammatory cell functions, and …
such as free-radical scavenging, effects on immune and inflammatory cell functions, and …
Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features
Generation and accumulation of the amyloid β peptide (Aβ) following proteolytic processing
of the amyloid precursor protein (APP) by BACE-1 (Beta-site APP Cleaving Enzyme-1, β …
of the amyloid precursor protein (APP) by BACE-1 (Beta-site APP Cleaving Enzyme-1, β …
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
Aging, a fundamental physiological process influenced by innumerable biological and
genetic pathways, is an important driving factor for several aging‐associated disorders like …
genetic pathways, is an important driving factor for several aging‐associated disorders like …
Rutin as a natural therapy for Alzheimer's disease: Insights into its mechanisms of action
S Habtemariam - Current medicinal chemistry, 2016 - ingentaconnect.com
Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside with
profound effects on the various cellular functions under pathological conditions. Due to the …
profound effects on the various cellular functions under pathological conditions. Due to the …
Drug development for Alzheimer's disease: where are we now and where are we headed?
MN Sabbagh - The American journal of geriatric pharmacotherapy, 2009 - Elsevier
Objective: The aim of this article was to provide a survey of the clinical development of
pharmacotherapy for Alzheimer's disease (AD). Methods: A search of PubMed to identify …
pharmacotherapy for Alzheimer's disease (AD). Methods: A search of PubMed to identify …
Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases
The socioeconomic burden of multi-factorial pathologies, such as neurodegenerative
diseases (NDs), is enormous worldwide. Unfortunately, no proven disease-modifying …
diseases (NDs), is enormous worldwide. Unfortunately, no proven disease-modifying …