DNA copy number variation has long been associated with specific chromosomal
rearrangements and genomic disorders, but its ubiquity in mammalian genomes was not …

Compared with other mammals, the genomes of humans and other primates show an
enrichment of large, interspersed segmental duplications (SDs) with high levels of sequence …

The role of structurally dynamic genomic regions in speciation is poorly understood due to
challenges inherent in diploid genome assembly. Here we reconstructed the evolutionary …

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris),
together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The …

A comparison of gene content and genome architecture of Trypanosoma brucei,
Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles …

The human genome contains numerous blocks of highly homologous duplicated sequence.
This higher-order architecture provides a substrate for recombination and recurrent …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

The genome organizations of eight phylogenetically distinct species from five mammalian
orders were compared in order to address fundamental questions relating to mammalian …

Detailed linkage and recombination rate maps are necessary to use the full potential of
genome sequencing and population genomic analyses. We used a custom collared …

Structural variation (SV) is a rich source of genetic diversity in mammals, but due to the
challenges associated with mapping SV in complex genomes, basic questions regarding …