Tissue factor, blood coagulation, and beyond: an overview

AJ Chu - International journal of inflammation, 2011 - Wiley Online Library
Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

[HTML][HTML] Macrophage inflammatory protein-2 as mediator of inflammation in acute liver injury

CC Qin, YN Liu, Y Hu, Y Yang… - World journal of …, 2017 - ncbi.nlm.nih.gov
Abstract Macrophage inflammatory protein (MIP)-2 is one of the CXC chemokines and is
also known as chemokine CXC ligand (CXCL2). MIP-2 affects neutrophil recruitment and …

[HTML][HTML] Inflammation and cell death during cholestasis: the evolving role of bile acids

BL Woolbright, H Jaeschke - Gene expression, 2019 - ncbi.nlm.nih.gov
Cholestasis results in blockage of bile flow whether the point of obstruction occurs
extrahepatically or intrahepatically. Bile acids are a primary constituent of bile, and thus one …

Therapeutic targets for cholestatic liver injury

BL Woolbright, H Jaeschke - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Cholestasis is a reduction in bile flow that occurs during numerous pathologies.
Blockage of the biliary tracts results in hepatic accumulation of bile acids or their conjugate …

Inflammation: Cause or consequence of chronic cholestatic liver injury

BL Woolbright - Food and Chemical Toxicology, 2020 - Elsevier
Cholestasis is a result of obstruction of the biliary tracts. It is a common cause of liver
pathology after exposure to toxic xenobiotics and during numerous other liver diseases …

Coagulation in liver toxicity and disease: role of hepatocyte tissue factor

AK Kopec, JP Luyendyk - Thrombosis research, 2014 - Elsevier
The liver is the primary source of a number of circulating coagulation factors, and acute liver
injury and chronic liver disease are each associated with alterations in blood coagulation …

Modulation of thioacetamide-induced hepatic inflammations, angiogenesis and fibrosis by andrographolide in mice

TY Lee, HH Chang, CK Wen, TH Huang… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Liver fibrosis is a complex disease in which several
pathological processes, such as inflammation and angiogenesis, are closely integrated …

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury

PE Rautou, K Tatsumi, S Antoniak, AP Owens III… - Journal of …, 2016 - Elsevier
Background & Aims Patients with chronic liver disease and cirrhosis have a dysregulated
coagulation system and are prone to thrombosis. The basis for this hypercoagulable state is …

Xenobiotic-induced liver injury and fibrosis

CH Österreicher, M Trauner - Expert opinion on drug metabolism & …, 2012 - Taylor & Francis
Introduction: Many different drugs and xenobiotics (chemical compounds foreign to an
organism) can injure the bile duct epithelium and cause inflammatory bile duct diseases …

Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism

C Niu, Y Sheng, E Zhu, L Ji, Z Wang - Bioscience trends, 2016 - jstage.jst.go.jp
The rhizome of Dioscorea bulbifera Linn, traditionally used to treat thyroid disease and
cancer in China, is reported to induce serious liver injury during clinical practice. Diosbulbin …