Long QT syndromes can be either acquired or congenital. Drugs are one of the many
etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used …

Background Scorpions have evolved a highly efficient venom that serves both to capture
prey and for self-defense. As a result, peptides isolated from the venom of various scorpion …

Photoactivatable drugs targeting ligand-gated ion channels open up new opportunities for
light-guided therapeutic interventions. Photoactivable toxins targeting ion channels have the …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) constitute an appealing
tool for drug discovery, disease modeling, and cardiotoxicity screening. However, their …

A mutation to serine of a conserved threonine (T634S) in the hERG K+ channel S6 pore
region has been identified as a variant of uncertain significance, showing a loss-of-function …

Background Long QT Syndrome (LQTS) is a rare cardiac disorder characterized by
prolonged ventricular repolarization and increased risk of ventricular arrhythmias. This …

Cardiac rhythm, conduction, and electrical activity synchronization require the coordinated
action of several ion channel types that differ according to the transmural and regional …

In recent years, peptides have received increased interest in pharmaceutical, food,
cosmetics, and various other fields. The high potency, specificity, and good safety profile are …

Le syndrome du QT long de type 2 (SQTL2) héréditaire est un trouble du rythme cardiaque,
causé par des mutations perte de fonction dans le gène KCNH2, codant pour le canal …

Cardiac arrhythmia (CA) is a heart disease characterized by disruptions in the heart's
rhythm, resulting in abnormal excitation or conduction of cardiac electrical signals, which in …