Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

K Peng, Y Zheng, W Xia, ZW Mao - Chemical Society Reviews, 2023 - pubs.rsc.org
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Cuproptosis: Harnessing transition metal for cancer therapy

W Wang, W Mo, Z Hang, Y Huang, H Yi, Z Sun, A Lei - ACS nano, 2023 - ACS Publications
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

[HTML][HTML] Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

[HTML][HTML] Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

N Singh, J Kim, J Kim, K Lee, Z Zunbul, I Lee, E Kim… - Bioactive materials, 2023 - Elsevier
Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing
research area. The unique properties of nanomedicines have a massive potential in solving …

[HTML][HTML] Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy

L Cao, H Tian, M Fang, Z Xu, D Tang, J Chen, J Yin… - Biomaterials, 2022 - Elsevier
Abstract cGAS-STING pathway, as an essential intracellular immune response pathway, has
attracted much attention in tumor immunotherapy. However, low metabolic stability of …

Poly (ethylene glycol) alternatives in biomedical applications

X Yao, C Qi, C Sun, F Huo, X Jiang - Nano Today, 2023 - Elsevier
Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Engineered bacteria labeled with iridium (III) photosensitizers for enhanced photodynamic immunotherapy of solid tumors

W Lin, Y Liu, J Wang, Z Zhao, K Lu, H Meng… - Angewandte …, 2023 - Wiley Online Library
Despite metal‐based photosensitizers showing great potential in photodynamic therapy for
tumor treatment, the application of the photosensitizers is intrinsically limited by their poor …

Biomedical metal–organic framework materials: perspectives and challenges

A Wang, M Walden, R Ettlinger… - Advanced Functional …, 2023 - Wiley Online Library
Metal–organic framework (MOF) materials are gaining significant interest in biomedical
research, owing to their high porosity, crystallinity, and structural and compositional diversity …