Bacterial protein secretion systems: game of types
A Filloux - Microbiology, 2022 - microbiologyresearch.org
Protein trafficking across the bacterial envelope is a process that contributes to the
organisation and integrity of the cell. It is the foundation for establishing contact and …
organisation and integrity of the cell. It is the foundation for establishing contact and …
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia
M Hagan, G Pankov, R Gallegos-Monterrosa… - Nature …, 2023 - nature.com
Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial
effector proteins into neighbouring bacterial cells, representing an important mechanism of …
effector proteins into neighbouring bacterial cells, representing an important mechanism of …
N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system
F Jiang, J Shen, J Cheng, X Wang, J Yang, N Li… - Science …, 2022 - science.org
Extracellular contractile injection systems (eCISs) are widespread bacterial nanomachines
that resemble T4 phage tail. As a typical eCIS, Photorhabdus virulence cassette (PVC) was …
that resemble T4 phage tail. As a typical eCIS, Photorhabdus virulence cassette (PVC) was …
Structure of a bacterial Rhs effector exported by the type VI secretion system
The t ype VI s ecretion s ystem (T6SS) is a widespread protein export apparatus found in
Gram-negative bacteria. The majority of T6SSs deliver toxic effector proteins into competitor …
Gram-negative bacteria. The majority of T6SSs deliver toxic effector proteins into competitor …
Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA
Bacteria have evolved sophisticated mechanisms to deliver potent toxins into bacterial
competitors or into eukaryotic cells in order to destroy rivals and gain access to a specific …
competitors or into eukaryotic cells in order to destroy rivals and gain access to a specific …
Dual targeting factors are required for LXG toxin export by the bacterial type VIIb secretion system
Bacterial type VIIb secretion systems (T7SSb) are multisubunit integral membrane protein
complexes found in Firmicutes that play a role in both bacterial competition and virulence by …
complexes found in Firmicutes that play a role in both bacterial competition and virulence by …
Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin
Bacteria have evolved toxins to outcompete other bacteria or to hijack host cell pathways.
One broad family of bacterial polymorphic toxins gathers multidomain proteins with a …
One broad family of bacterial polymorphic toxins gathers multidomain proteins with a …
A binary effector module secreted by a type VI secretion system
Gram‐negative bacteria use type VI secretion systems (T6SSs) to deliver toxic effector
proteins into neighboring cells. Cargo effectors are secreted by binding noncovalently to the …
proteins into neighboring cells. Cargo effectors are secreted by binding noncovalently to the …
The breadth and molecular basis of Hcp-driven type VI secretion system effector delivery
SA Howard, RCD Furniss, D Bonini, H Amin… - MBio, 2021 - Am Soc Microbiol
The type VI secretion system (T6SS) is a bacterial nanoscale weapon that delivers toxins
into prey ranging from bacteria and fungi to animal hosts. The cytosolic contractile sheath of …
into prey ranging from bacteria and fungi to animal hosts. The cytosolic contractile sheath of …