Novel therapeutics for the treatment of hypertension and its associated complications: peptide-and nonpeptide-based strategies

T Ghatage, SG Goyal, A Dhar, A Bhat - Hypertension Research, 2021 - nature.com
The renin-angiotensin-aldosterone system (RAAS) is responsible for maintaining blood
pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential …

Recent advances in the development of therapeutic peptides

J Fetse, S Kandel, UF Mamani, K Cheng - Trends in Pharmacological …, 2023 - cell.com
Peptides have unique characteristics that make them highly desirable as therapeutic agents.
The physicochemical and proteolytic stability profiles determine the therapeutic potential of …

Purification, molecular docking and in vivo analyses of novel angiotensin-converting enzyme inhibitory peptides from protein hydrolysate of moth bean (Vigna …

A Bhadkaria, DT Narvekar, DP Nagar, SP Sah… - International Journal of …, 2023 - Elsevier
The moth bean is a high-protein food legume. Enzymatic hydrolysates of food proteins
demostrate health benefits. Search for diet related food protein hydrolysates is therefore …

Emergent peptides of the antifibrotic arsenal: taking aim at myofibroblast promoting pathways

Z Liu, X Zhang, Y Wang, Y Tai, X Yao, AC Midgley - Biomolecules, 2023 - mdpi.com
Myofibroblasts are the principal effector cells driving fibrosis, and their accumulation in
tissues is a fundamental feature of fibrosis. Essential pathways have been identified as …

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

D Kartchner, K McCoy, J Dubey, D Zhang, K Zheng… - Biology, 2023 - mdpi.com
Simple Summary Given the prevalence of COVID-19 infection, assessment of sequelae is
critical to public health. Recent studies revealed a higher incidence of resistant hypertension …

The protective effects of tripeptides VPP and IPP against small extracellular vesicles from angiotensin II-induced vascular smooth muscle cells mediating endothelial …

T Song, M Lv, L Zhang, X Zhang, G Song… - Journal of Agricultural …, 2020 - ACS Publications
Endothelial dysfunction is a common disorder of vascular homeostasis in hypertension
characterized by oxidative stress, malignant migration, inflammatory response, and active …

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

LP Tardelli, F Duchatsch, NA Herrera… - Journal of Applied …, 2021 - Wiley Online Library
Dexamethasone (DEX)‐induced hypertension is observed in normotensive rats, but little is
known about the effects of DEX on spontaneously hypertensive animals (SHR). This study …

ACE 2/Ang (1-7)/Mas, Non-conventional RAS Axis: Endogenous Contributor of Cardio, and Reno-protective Responses

S Sarkar, K Jayachandra… - Journal of Cellular …, 2024 - scientificarchives.com
The Renin angiotensin system (RAS) is an intricate pathway that regulates homeostasis.
The proliferative arm of RAS that includes angiotensin converting enzyme (ACE) …

Serum Angiotensin-Converting Enzyme Methylation Level and Its Significance in Patients With Comorbid Major Depressive Disorder and Hypertension

G Abula, J Li, R Ma, T Zhang, A Aji… - Clinical …, 2023 - journals.lww.com
Objective Major depressive disorder (MDD) often coexists with hypertension (HYT). DNA
methylation has elicited vital functionality in their development. Angiotensin-converting …

[PDF][PDF] Mechanizmy unikania wrodzonej odpowiedzi immunologicznej przez ludzkie koronawirusy

R SZEWCZYK, J KALINOWSKA, M CHAŁUBIŃSKI - 2023 - researchgate.net
Układ odporności wrodzonej stanowi pierwszą linię obrony gospodarza przed otaczającymi
go patogenami. W przypadku infekcji wirusowych, jako iż są to patogeny …