Advancements in CHO metabolomics: techniques, current state and evolving methodologies

R Singh, E Fatima, L Thakur, S Singh… - … in Bioengineering and …, 2024 - frontiersin.org
Background: Investigating the metabolic behaviour of different cellular phenotypes, ie,
good/bad grower and/or producer, in production culture is important to identify the key …

Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells

SL Geng, XJ Zhao, X Zhang, JH Zhang, CL Mi… - Applied Microbiology …, 2024 - Springer
Mammalian cell lines are frequently used as the preferred host cells for producing
recombinant therapeutic proteins (RTPs) having post-translational modified modification …

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

F Lukšić, A Mijakovac, G Josipović, V Vičić Bočkor… - Biomolecules, 2023 - mdpi.com
Glycosylation of IgG regulates the effector function of this antibody in the immune response.
Glycosylated IgG is a potent therapeutic used for both research and clinical purposes. While …

Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking

M Dorn, C Ferng, K Klottrup-Rees, K Lee… - … in Bioengineering and …, 2025 - frontiersin.org
Bioprocessing has been transitioning from batch to continuous processes. As a result, a
considerable amount of resource was dedicated to optimising strategies for continuous …

Implementation of a high throughput screening assay to identify and characterize insecticides acting on ion channels

A Brockmann - 2023 - bonndoc.ulb.uni-bonn.de
With 800 million people suffering from hunger, new innovative crop protection products are
required to ensure food supply and stop hunger. The voltage-sensitive sodium channel …

The role of mitochondrial translocator protein 18kDa (TSPO) in regulating astrocyte metabolism

W Firth - 2023 - search.proquest.com
Astrocytes, a heterogeneous class of glial cells, play key roles in maintaining homeostasis in
the central nervous system (CNS). This is achieved through multifaceted cellular responses; …