Role of paraoxonase 1 in organophosphate G-series nerve agent poisoning and future therapeutic strategies

RK Tripathy, PY Khandave, J Bzdrenga, F Nachon… - Archives of …, 2024 - Springer
Chemical warfare nerve agents (CWNA) are neurotoxic chemicals unethically used as
agents of mass destruction by terrorist outfits and during war. The available antidote against …

Oxidized high density lipoprotein induces macrophage apoptosis via toll-like receptor 4-dependent CHOP pathway

S Yao, H Tian, L Zhao, J Li, L Yang, F Yue, Y Li… - Journal of lipid …, 2017 - ASBMB
Oxidized HDL (ox-HDL), unlike native HDL that exerts antiatherogenic effects, plays a
proatherogenic role. However, the underlying mechanisms are not completely understood …

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

R Yadav, M France… - The Journal of …, 2014 - academic.oup.com
Context: Obstructive sleep apnea (OSA) complicates morbid obesity and is associated with
increased cardiovascular disease incidence. An increase in the circulating markers of …

The effect of dual antioxidant modification on oxidative stress resistance and anti-dysfunction of non-split HDL and recombinant HDL

S Xu, X Huang, Y Wang, J Liu, W Zhang - International Journal of Biological …, 2024 - Elsevier
Recombinant high-density lipoprotein (rHDL) as anti-atherosclerosis (AS) vehicle has
unique advantages including multiple anti-atherogenic functions and homing features to …

Endoplasmic reticulum stress‐dependent autophagy inhibits glycated high‐density lipoprotein‐induced macrophage apoptosis by inhibiting CHOP pathway

H Tian, Y Li, P Kang, Z Wang, F Yue… - Journal of Cellular …, 2019 - Wiley Online Library
This study was designed to explore the inductive effect of glycated high‐density lipoprotein
(gly‐HDL) on endoplasmic reticulum (ER) stress‐C/EBP homologous protein (CHOP) …

The discovery and investigation of a crystalline solid solution of an active pharmaceutical ingredient

MA Patel, MHH AbouGhaly, K Chadwick - International journal of …, 2017 - Elsevier
Understanding the phase behavior of crystal forms is essential in drug formulation
development, as physical stability of the active pharmaceutical ingredient (API) is critical to …

Oxidized high‐density lipoprotein accelerates atherosclerosis progression by inducing the imbalance between treg and teff in LDLR knockout mice

D Ru, H Zhiqing, Z Lin, W Feng, Z Feng, Z Jiayou… - Apmis, 2015 - Wiley Online Library
High density lipoprotein (HDL) dysfunction has been widely reported in clinic, and oxidation
of HDL (ox‐HDL) was shown to be one of the most common modifications in vivo and …

Refolded recombinant human paraoxonase 1 variant exhibits prophylactic activity against organophosphate poisoning

P Bajaj, RK Tripathy, G Aggarwal, AK Datusalia… - Applied biochemistry …, 2016 - Springer
Organophosphate (OP) compounds are neurotoxic chemicals, and current treatments
available for OP-poisoning are considered as unsatisfactory and inadequate. There is an …

A green-inspired method to prepare non-split high-density lipoprotein (HDL) carrier with anti-dysfunctional activities superior to reconstituted HDL

Y Wang, X Huang, D Yang, J He, Z Chen, K Li… - European Journal of …, 2023 - Elsevier
Numerous studies have demonstrated that dysfunctional high-density lipoprotein (HDL),
especially oxidized HDL (OxHDL), could generate multifaceted in vivo proatherogenic …

HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: In vivo and in vitro studies

M Rosenblat, N Volkova, M Aviram - BioFactors, 2014 - Wiley Online Library
We analyzed in‐vivo and in‐vitro high density lipoprotein (HDL) effects on paraoxonase 1
(PON1) antiatherogenic properties in serum and in macrophages. Intraperitoneal injection to …