Pseudomonas aeruginosa is a metabolically versatile bacterium that can cause a wide
range of severe opportunistic infections in patients with serious underlying medical …

Inflammation is a natural host defensive process that is largely regulated by macrophages
during the innate immune response. Mitogen‐activated protein kinases (MAPKs) are proline …

Background Frailty is common in seniors and is characterized by diminished physiological
reserves and increased vulnerability to stressors. Frailty can change the prognosis and …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death
worldwide and has few effective therapies. It is characterized by anomalous and persistent …

Lung function declines with advancing age. To improve our understanding of the structure-
function relationships leading to this decline, we investigated structural alterations in the …

Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and
environmental compound is one of the leading causes of death in worldwide. This disease is …

Systemic inflammation that occurs with increasing age (inflammaging) is thought to
contribute to the increased susceptibility of the elderly to several disease states. The elderly …

COPD (chronic obstructive pulmonary disease) is associated with sustained inflammation,
excessive injury, and accelerated lung aging. Human Klotho (KL) is an anti-aging protein …

Chronic airway inflammation from recurring exposures to noxious environmental stimuli
results in a progressive and irreversible airflow limitation and the lung parenchymal damage …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterized by varying degrees of emphysematous lung destruction and small airway …