Cardioprotection and its translation: a need for new paradigms? Or for new pragmatism? An opinionated retro-and perspective

G Heusch - Journal of Cardiovascular Pharmacology and …, 2023 - journals.sagepub.com
The dawn of cardioprotection by infarct size reduction originated from the idea to favourably
alter the oxygen demand–supply balance of the ischaemic/infarcting myocardium by …

Noble gases therapy in cardiocerebrovascular diseases: the novel stars?

J Zhang, W Liu, M Bi, J Xu, H Yang… - Frontiers in …, 2022 - frontiersin.org
Cardiocerebrovascular diseases (CCVDs) are the leading cause of death worldwide;
therefore, to deeply explore the pathogenesis of CCVDs and to find the cheap and efficient …

Treatment with inhaled Argon: a systematic review of pre-clinical and clinical studies with meta-analysis on neuroprotective effect

G Merigo, G Florio, F Madotto, A Magliocca, I Silvestri… - …, 2024 - thelancet.com
Summary Background Argon (Ar) has been proposed as a potential therapeutic agent in
multiple clinical conditions, specifically in organ protection. However, conflicting data on pre …

Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury

H Qi, J Zhang, Y Shang, S Yuan, C Meng - Bioengineered, 2021 - Taylor & Francis
The objective of this study was to explore the effect of argon preconditioning on myocardial
ischemia reperfusion (MI/R) injury and its mechanism. Cardiomyocytes H2C9 were pre …

Positive neuroprotective effect of Argon inhalation after photochemically induced ischemic stroke model in rats

DN Silachev, EA Boeva, EI Yakupova… - Bulletin of Experimental …, 2023 - Springer
We studied the effect of 2-h inhalation of argon-oxygen mixture (Ar 70%/O2 30%) after
photochemically induced stroke and on days 2 and 3 after stroke modeling on the severity of …

Ventilation with argon improves survival with good neurological recovery after prolonged untreated cardiac arrest in pigs

F Fumagalli, D Olivari, A Boccardo… - Journal of the …, 2020 - Am Heart Assoc
Background Ventilation with the noble gas argon (Ar) has shown neuroprotective and
cardioprotective properties in different in vitro and in vivo models. Hence, the …

Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress

F Li, X Geng, H Lee, M Wills, Y Ding - Frontiers in Cellular …, 2021 - frontiersin.org
While it is well-known that pre-stroke exercise conditioning reduces the incidence of stroke
and the development of comorbidities, it is unclear whether post-stroke exercise …

A complete review of preclinical and clinical uses of the noble gas argon: evidence of safety and protection

F Nespoli, S Redaelli, L Ruggeri… - Annals of Cardiac …, 2019 - journals.lww.com
The noble gas argon (Ar) is a “biologically” active element and has been extensively studied
preclinically for its organ protection properties. This work reviews all preclinical studies …

Phosphodiesterase inhibitor, Vinpocetine, guards against doxorubicin induced cardiotoxicity via modulation of HIF/VEGF and cGMP/cAMP/SIRT signaling pathways

MMM Refaie, M El-Hussieny… - Human & …, 2022 - journals.sagepub.com
Purpose: Doxorubicin (DOX) is a widely used chemotherapeutic agent complicated with
cardiotoxic adverse effects. Up till now, there are no researches discussing the role of …

Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

A Martusevich, A Surovegina… - BioMed Research …, 2022 - Wiley Online Library
The aim of the study was to assess the effect of external use of inert gases (helium and
argon) on the state of free radical processes in vivo. The experiment was performed on 30 …