Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

The inability to predict long noncoding RNAs from genomic sequence has impeded the use
of comparative genomics for studying their biology. Here, we develop methods that use RNA …

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse
cellular processes. Determining the function of individual lincRNAs remains a challenge …

HAND2 is an ancestral regulator of heart development and one of four transcription factors
that control the reprogramming of fibroblasts into cardiomyocytes,,,. Deletion of Hand2 in …

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long
noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how …