There have been innumerate demonstrations of p53's activity as a tumour suppressor
protein with the ability to stimulate cell signalling that can lead to cell cycle arrest and cell …

During DNA replication, forks may encounter unrepaired lesions that hamper DNA
synthesis. Cells have universal strategies to promote damage bypass allowing cells to …

Spaceflight-associated immune system weakening ultimately limits the ability of humans to
expand their presence beyond the earth's orbit. A mechanistic study of microgravity …

Genome lesions trigger biological responses that help cells manage damaged DNA,
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …

I. Введение. II. Модуляция активности р53. III. p53 убивает или останавливает деления
поврежденных клеток, тем самым сни жая вероятность возникновения рака. IV …

Methylene blue plus visible light (MB+ VL) results in oxidative DNA damage, producing
predominantly 7, 8-dihydroxy-8-oxoguanine and other single base modifications that are …

The p53 tumor suppressor serves to secure genetic stability of multicellular organisms. It
suppresses the accumulation of mutations in somatic cells and substantially decreases the …

The effect of lipopolysaccharide (LPS) on the expression of p53 protein in RAW 264.7
macrophage cells was examined. LPS downregulated the expression of p53 protein 4–24 h …

In response to ultraviolet radiation (UV), mammalian cells rapidly activate a nuclear enzyme
poly (ADP-ribose) polymerase-1 (PARP), and we recently showed that one of the causes for …

Hypoxia and low pH are commonly associated with the tumor microenvironment. We have
examined the effects of hypoxia alone (HA) and hypoxia coupled to low pH (HApH) on p53 …