Recent trends in protein and peptide-based biomaterials for advanced drug delivery

A Varanko, S Saha, A Chilkoti - Advanced drug delivery reviews, 2020 - Elsevier
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Temperature-responsive compounds as in situ gelling biomedical materials

HJ Moon, MH Park, MK Joo, B Jeong - Chemical Society Reviews, 2012 - pubs.rsc.org
Aqueous solutions that undergo sol-to-gel transition as the temperature increases have
been extensively studied during the last decade. The material can be designed by …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

Cooperativity principles in self-assembled nanomedicine

Y Li, Y Wang, G Huang, J Gao - Chemical reviews, 2018 - ACS Publications
Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the
prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular …

Effects of pH alterations on stress-and aging-induced protein phase separation

X Jin, M Zhou, S Chen, D Li, X Cao, B Liu - Cellular and Molecular Life …, 2022 - Springer
Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to
fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The …

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

S Hajebi, S Yousefiasl, I Rahimmanesh… - Advanced …, 2022 - Wiley Online Library
Conventional drug delivery systems are challenged by concerns related to systemic toxicity,
repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery …

Implications of protein-and peptide-based nanoparticles as potential vehicles for anticancer drugs

AO Elzoghby, MM Elgohary, NM Kamel - Advances in protein chemistry …, 2015 - Elsevier
Protein-based nanocarriers have gained considerable attention as colloidal carrier systems
for the delivery of anticancer drugs. Protein nanocarriers possess various advantages …

A Unified Model for De Novo Design of Elastin-like Polypeptides with Tunable Inverse Transition Temperatures

JR McDaniel, DC Radford, A Chilkoti - Biomacromolecules, 2013 - ACS Publications
Elastin-like polypeptides (ELPs) are stimulus-responsive peptide polymers that exhibit
inverse temperature phase transition behavior, causing an ELP to aggregate above its …

Drug delivery to solid tumors by elastin-like polypeptides

JR McDaniel, DJ Callahan, A Chilkoti - Advanced drug delivery reviews, 2010 - Elsevier
Thermally responsive elastin-like polypeptides (ELPs) are a promising class of recombinant
biopolymers for the delivery of drugs and imaging agents to solid tumors via systemic or …