Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …

The understanding of the pathogenesis and mechanisms of diseases requires a
multidisciplinary approach, involving clinical observation, correlation to pathological …

Transmissible spongiform encephalopathies (TSE s) are untreatable, fatal neurologic
diseases affecting mammals. Human disease forms include sporadic, familial and acquired …

The human prion diseases are a diverse set of often rapidly progressive neurodegenerative
conditions associated with abnormal forms of the prion protein. We review work to establish …

Neurodegenerative disorders of the central nervous system (CNS) and brain traumatic
insults are characterized by complex overlapping pathophysiological alterations …

Efforts to prevent human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD)
by contaminated blood would be aided by the development of a sensitive diagnostic test that …

Currently, there is a lack of pathological landmarks to describe the progression of prion
disease in vivo. Our goal was to use an experimental model to determine the temporal …

Aims In the search for blood‐based biomarkers of neurodegenerative diseases, we
characterized the concentration of total prion protein (t‐PrP) in the plasma of …

Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease thought to have been
transmitted to humans through the consumption of food products contaminated with bovine …

Abstract Variant Creutzfeldt-Jakob disease (vCJD) is a devastating disease caused by
transmission of bovine spongiform encephalopathy to humans. Although vCJD cases are …